| Identification |
| Name: | 1H-Pyrazolo[3,4-d]pyrimidin-4-amine,1-(1,1-dimethylethyl)-3-(1-naphthalenyl)- |
| Synonyms: | 1-NA-PP 1 |
| CAS: | 221243-82-9 |
| Molecular Formula: | C19H19 N5 |
| Molecular Weight: | 317.39 |
| InChI: | InChI=1/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22) |
| Molecular Structure: |
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| Properties |
| Flash Point: | 273°C |
| Boiling Point: | 527.8°Cat760mmHg |
| Density: | 1.27g/cm3 |
| Refractive index: | 1.688 |
| Appearance: | White cyrstalline solid |
| Biological Activity: | Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC 50 values are 1.0, 0.6, 0.6, 18 and 22 μ M for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC 50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively). |
| Flash Point: | 273°C |
| Usage: | A highly potent (IC50=1.5nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase |
| Safety Data |
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