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3,4-Pyrrolidinediol,2-[(4-methoxyphenyl)methyl]-, 3-acetate, (2R,3S,4S)- (22862-76-6)

Identification
Name:3,4-Pyrrolidinediol,2-[(4-methoxyphenyl)methyl]-, 3-acetate, (2R,3S,4S)-
Synonyms:3,4-Pyrrolidinediol,2-(p-methoxybenzyl)-, 3-acetate, (2R,3S,4S)- (8CI);3,4-Pyrrolidinediol,2-[(4-methoxyphenyl)methyl]-, 3-acetate, [2R-(2a,3a,4b)]-;Anisomycin (6CI,7CI);(-)-Anisomycin;(2R,3S,4S)-2-(p-Methoxybenzyl)-3,4-pyrrolidinediol 3-acetate;(2R,3S,4S)-2-(p-Methoxyphenylmethyl)-3-acetoxy-4-hydroxypyrrolidine;Anisomycin, (-)-;Flagecidin;NSC 76712;
CAS:22862-76-6
EINECS: 245-269-7
Molecular Formula: C14H19NO4
Molecular Weight: 265.30496
InChI: InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1
Molecular Structure: (C14H19NO4) 3,4-Pyrrolidinediol,2-(p-methoxybenzyl)-, 3-acetate, (2R,3S,4S)- (8CI);3,4-Pyrrolidinediol,2-[(4-met...
Properties
Transport:UN 3462 6
Melting Point: 140-141 C
Density:1.21 g/cm3
Stability:Stable. Incompatible with strong oxidizing agents.
Water Solubility:methanol: 20 mg/mL, clear, colorless to faintly yellow
Solubility:methanol: 20 mg/mL, clear, colorless to faintly yellow
Appearance:White crystalline solid
Specification:

 Anisomycin ,its cas register number is 22862-76-6. It also can be called Flagecidin ; 4-Hydroxy-2-(4-methoxybenzyl)-3-pyrrolidinylacetat ; Acétate de 4-hydroxy-2-(4-méthoxybenzyl)-3-pyrrolidinyle and 3,4-pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, 3-acetate . It is inactive against bacteria, and can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis.

Packinggroup: III
Biological Activity: Protein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).
Storage Temperature: 2-8°C
Color: white
Safety Data
Hazard Symbols T: Toxic
 

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