2,4,6,8-Decatetraenedioicacid,1-[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl]ester, (2E,4E,6E,8E)- (23110-15-8)

Identification
Name:	2,4,6,8-Decatetraenedioicacid,1-[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl]ester, (2E,4E,6E,8E)-
Synonyms:	2,4,6,8-Decatetraenedioicacid 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro[2.5]oct-6-ylester (6CI);2,4,6,8-Decatetraenedioic acid,mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl]ester, (2E,4E,6E,8E)- (9CI);2,4,6,8-Decatetraenedioic acid,mono[4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro[2.5]oct-6-yl]ester (8CI);2,4,6,8-Decatetraenedioic acid,mono[5-methoxy-4-[2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl]ester, [3R-[3a,4a(2R,3R),5b,6b(2E,4E,6E,8E)]]-;Amebacilin;Fugillin;Fumadil B;Fumagillin;Fumagillin DCH;Fumidil;NSC 9168;297-95-0;
CAS:	23110-15-8
EINECS:	245-433-8
Molecular Formula:	C₂₆H₃₄O₇
Molecular Weight:	458.54396
InChI:	InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20?,23-,24-,25?,26+/m1/s1
Molecular Structure:
Properties
Flash Point:	198.8°C
Boiling Point:	608.8°Cat760mmHg
Density:	1.19g/cm³
Refractive index:	1.562
Water Solubility:	Soluble in chloroform or diluted aqueous bases. Slightly soluble in methanol and other alcoholic solvents. Insoluble in water.
Solubility:	Soluble in chloroform or diluted aqueous bases. Slightly soluble in methanol and other alcoholic solvents. Insoluble in water.
Appearance:	Light yellow solid
Biological Activity:	Antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo . Also inhibits tumor growth in mice. Analog available, TNP 470 (N-(2-Chloroacetyl)carbamic acid (3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl -2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester).
Flash Point:	198.8°C
Storage Temperature:	−20°C
Color:	white
Safety Data
Hazard Symbols	Xn: Harmful

2,4,6,8-Decatetraenedioicacid,1-[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl]ester, (2E,4E,6E,8E)- (23110-15-8)

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