| Identification | |
| Name: | Homoharringtonine |
| Synonyms: | Cephalotaxine,4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), [3(R)]-;Homoharringtonine (8CI);CGX 635;Ceflatonin;Myelostat;NSC 141633;Omacetaxine mepesuccinate;Ephalotaxine, 4-methyl(2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester); |
| CAS: | 26833-87-4 |
| Molecular Formula: | C29H39NO9 |
| Molecular Weight: | 545.62126 |
| InChI: | InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25+,28-,29?/m0/s1 |
| Molecular Structure: | ![(C29H39NO9) Cephalotaxine,4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), [3(R)]-;Homoharri...](https://img.guidechem.com/casimg/26833-87-4.gif) |
| Properties | |
| Transport: | UN 1544 6 |
| Melting Point: | 144-146 °C |
| Flash Point: | 385.1 ºC |
| Boiling Point: | 713.1 ºC at 760 mmHg |
| Density: | 1.33 g/cm3 |
| Refractive index: | 1.604 |
| Water Solubility: | Soluble in DMSO or 100% ethanol. |
| Solubility: | Soluble in DMSO or 100% ethanol. |
| Appearance: | Off-white Cryst |
| Specification: |
? Homoharringtonine (CAS NO.26833-87-4), its Synonyms are 1-((1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H-cyclopenta(a)(1,3)dioxolo(4,5-h)pyrrolo(2,1-b)(3)benzazepin-1-yl) 4-methyl (2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate ; Ceflatonin ; Myelostat ; Omacetaxine mepesuccinate ; Omapro ; Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester) (9CI) ; Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), (3(R))- (9CI) ; Cephalotaxine, 4-methyl-, 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester) ; Homoharringtonine (8CI) . |
| Packinggroup: | II |
| Biological Activity: | Inhibitor of protein synthesis. Blocks elongation phase of translation by binding to the 60-S ribosome subunit. Antileukemic. |
| Flash Point: | 385.1 ºC |
| Usage: | Homoharringtonine (HHT) combined with some botanical drugs could induce cancer cells to resemble normal cells. HHT was prepared by a semi-synthetic method from Cephalotaxine, a major alkaloid of Cepahlotaxus species through the formation of a-ketoes |
| Safety Data | |
| Hazard Symbols |
T+: Very toxic
Xi: Irritant
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