| Identification |
| Name: | Sphingosine 1-phosphate |
| Synonyms: | 4-Octadecene-1,3-diol,2-amino-, 1-(dihydrogen phosphate), (E)-D-erythro- (8CI);4-Octadecene-1,3-diol,2-amino-, 1-(dihydrogen phosphate), [R-[R*,S*-(E)]]-;(4E)-2-Amino-3-hydroxy-4-octadecen-1-yl dihydrogen phosphate;D-erythro-Sphingosine-1-phosphate;4-Octadecene-1,3-diol,2-amino-, 1-(dihydrogen phosphate), (2S,3R,4E)-;Sphingosine-1-phosphate;4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (4E)-; |
| CAS: | 26993-30-6 |
| Molecular Formula: | C18H38NO5P |
| Molecular Weight: | 379.471781 |
| InChI: | InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1 |
| Molecular Structure: |
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| Properties |
| Melting Point: | 190ºC |
| Density: | 1.094 g/cm3 |
| Water Solubility: | methanol: THF: water (6:3:1): >0.5 mg/mL |
| Solubility: | methanol: THF: water (6:3:1): >0.5 mg/mL |
| Appearance: | Off-White to Grey Powder |
| Biological Activity: | Endogenous second messenger involved in the control of cell proliferation and motility, and Ca 2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors, S1P 1-5 . Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase. |
| Storage Temperature: | −20°C |
| Color: | yellow |
| Usage: | A putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrations with no toxic effects thereby making it a possible agent for prevention of tumor cell metastasis and inflammatory processes; mobiliz |
| Safety Data |
| Hazard Symbols |
Xi: Irritant
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