Agaritine (2757-90-6)

  Agaritine with cas registry number of 2757-90-6 is colorless glistening crystals, called for CCRIS 5459 ; Glutamic acid, 5-(2-(alpha-hydroxy-p-tolyl)hydrazide), L- ; HSDB 4202 ; L-Glutamic acid, 5-(2-(4-(hydroxymethyl)phenyl)hydrazide) ; L-Glutamic acid, 5-(2-(alpha-hydroxy-para-tolyl)hydrazide) ; L-Glutamic acid, 5-(2-(4-(hydroxymethyl)phenyl)hydrazide) (9CI) ; NCI-C08899 ; beta-N-(gamma-L(+)Glutamyl)4-hydroxymethylphenylhydrazine ; beta-N-(alpha-L-Glutamyl)-4-hydroxymethylphenylhydrazine . Agaritine is totally degraded after 48 hours in aqueous solution with exposure to air and oxidizes rapidly upon storage. Agaritine exists in several mushroom species such as the genera Agaricus, Leucoagaricus, and Macrolepiota. The highest amount of agaritine is found in the cap and gills of the fruiting body, and the lowest in the stem. Agaritine has been shown to induce adenomas and adenocarcinomas in the lungs of mice when administered through drinking water.

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human No Adequate Data IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 31 , 1983,p. 63.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 31 , 1983,p. 63.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Studies (oral); No Evidence: mouse.