L-Cysteine,S-(triphenylmethyl)- (2799-07-7)

Identification
Name:	L-Cysteine,S-(triphenylmethyl)-
Synonyms:	Alanine,3-(tritylthio)-, L- (8CI);(2R)-2-Amino-3-[(triphenylmethyl)thio]propanoicacid;3-Tritylthio-L-alanine;NSC 83265;S-Triphenylmethyl-L-cysteine;S-Trityl-(R)-cysteine;S-Tritylcysteine;Tritylthioalanine;H-Cys(Trt)-OH;
CAS:	2799-07-7
EINECS:	218-195-8
Molecular Formula:	C₂₂H₂₁NO₂S
Molecular Weight:	363.47
InChI:	InChI=1/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)/t20-/m0/s1
Molecular Structure:
Properties
Density:	1.232 g/cm³
Refractive index:	111 ° (C=0.8, 0.04mol Ethanolic HCl)
Appearance:	almost white to light yellow granular powder
Specification:	Incompatibilities with Other Materials Strong oxidizing agents. Hazardous Decomposition Products Carbon monoxide, oxides of nitrogen, oxides of sulfur, carbon dioxide. Hazardous Polymerization Has not been reported.
Biological Activity:	Potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC 50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC 50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC 50 of 700 nM. Displays antitumor activity.
Storage Temperature:	-20°C
Safety Data
Hazard Symbols	Xn:Harmful