| Identification |
| Name: | TRAM-34 |
| Synonyms: | 1-[(2-Chlorophenyl)(diphenyl)methyl]-1H-pyrazole;1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole;1H-Pyrazole, 1-[(2-chlorophenyl)diphenylmethyl]- |
| CAS: | 289905-88-0 |
| Molecular Formula: | C22H17ClN2 |
| Molecular Weight: | 344.843 |
| InChI: | InChI=1/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H |
| Molecular Structure: |
![(C22H17ClN2) 1-[(2-Chlorophenyl)(diphenyl)methyl]-1H-pyrazole;1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole;1H-P...](https://img.guidechem.com/structure/289905-88-0.gif) |
| Properties |
| Flash Point: | 262.4°C |
| Boiling Point: | 510.2°C at 760 mmHg |
| Density: | 1.13g/cm3 |
| Refractive index: | 1.616 |
| Biological Activity: | Highly selective blocker of intermediate conductance Ca 2+ -activated K + channels (IK Ca 1, K Ca 3.1) (K d = 20 nM). Exhibits 200-1500-fold selectivity over K V , BK Ca , SK Ca , Na + , CRAC and Cl - channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli. |
| Flash Point: | 262.4°C |
| Storage Temperature: | 2-8°C |
| Color: | off-white |
| Usage: | TRAM-34 blocks intermediate conductance calcium-activated potassium channel IKCa1 with a Kd of 20nM and exhibits exquisite selectivity for the channel |
| Safety Data |
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