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L-Phenylalaninamide,N-[(2R,4R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl- (292632-98-5)

Identification
Name:L-Phenylalaninamide,N-[(2R,4R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-
Synonyms:36: PN:WO2005049027 PAGE: 99 claimed sequence; L 458; L 685458; g-Secretase inhibitor X
CAS:292632-98-5
Molecular Formula: C39H52 N4 O6
Molecular Weight: 672.85
Molecular Structure: (C39H52N4O6) 36: PN:WO2005049027 PAGE: 99 claimed sequence; L 458; L 685458; g-Secretase inhibitor X
Properties
Biological Activity: Potent and selective γ -secretase inhibitor (IC 50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC 50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro .
Storage Temperature: −20°C
Color: white
Safety Data
 

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