Identification |
Name: | L-Phenylalaninamide,N-[(2R,4R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl- |
Synonyms: | 36: PN:WO2005049027 PAGE: 99 claimed sequence; L 458; L 685458; g-Secretase inhibitor X |
CAS: | 292632-98-5 |
Molecular Formula: | C39H52 N4 O6 |
Molecular Weight: | 672.85 |
Molecular Structure: |
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Properties |
Biological Activity: | Potent and selective γ -secretase inhibitor (IC 50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC 50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro . |
Storage Temperature: | −20°C |
Color: | white |
Safety Data |
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