| Identification |
| Name: | 1-Piperazinamine,N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)- |
| Synonyms: | SANT 1 |
| CAS: | 304909-07-7 |
| Molecular Formula: | C23H27 N5 |
| Molecular Weight: | 373.49 |
| InChI: | InChI=1/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+ |
| Molecular Structure: |
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| Properties |
| Flash Point: | 284.8°C |
| Boiling Point: | 547.4°Cat760mmHg |
| Density: | 1.13g/cm3 |
| Refractive index: | 1.623 |
| Biological Activity: | Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (K D = 1.2 nM). Inhibits smoothened agonist effects with an IC 50 of 20 nM (in Shh-LIGHT2 cells). |
| Flash Point: | 284.8°C |
| Storage Temperature: | −20°C |
| Usage: | A potent antagonist of the sonic hedgehog (Shh) signaling pathway (IC50=20nm inShh-LIGHT2 assay an d in Ptch1-/- cells) that acts by binding to smoothened (Smo: KD=1.2 nM), a distant relative of G protein-coupled receptors. In contrast to cyclopami |
| Safety Data |
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