| Identification |
| Name: | Benzeneacetonitrile, a-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)- |
| Synonyms: | SL327 |
| CAS: | 305350-87-2 |
| Molecular Formula: | C16H12 F3 N3 S |
| Molecular Weight: | 335.35 |
| InChI: | InChI=1/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+ |
| Molecular Structure: |
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| Properties |
| Melting Point: | 127-128.2 °C
|
| Flash Point: | 263.8°C |
| Boiling Point: | 512.6°Cat760mmHg |
| Density: | 1.4g/cm3 |
| Refractive index: | 1.631 |
| Biological Activity: | Selective inhibitor of MEK1 and MEK2 (IC 50 values are 0.18 and 0.22 μ M respectively); blocks hippocampal LTP in vitro . Brain penetrant in vivo , blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration. |
| Flash Point: | 263.8°C |
| Storage Temperature: | 2-8°C |
| Color: | white |
| Safety Data |
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