1-Propanamine,N,N-diethyl-1,1,2,3,3,3-hexafluoro- (309-88-6)

The IUPAC name of N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine is N,N-diethyl-1,1,2,3,3,3-hexafluoropropan-1-amine. With the CAS registry number 309-88-6, it is also named as 1-Propanamine,N,N-diethyl-1,1,2,3,3,3-hexafluoro-. The product's categories are Fluorinated Building Blocks; Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds; Fluorination; Halogenation; Synthetic Organic Chemistry. Besides, it is clear colorless to yellow liquid, which should be stored away from flammables area. 

The other characteristics of this product can be summarized as: (1)ACD/LogP: 3.81; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.81; (4)ACD/LogD (pH 7.4): 3.81; (5)ACD/BCF (pH 5.5): 465.79; (6)ACD/BCF (pH 7.4): 465.83; (7)ACD/KOC (pH 5.5): 2828.01; (8)ACD/KOC (pH 7.4): 2828.29; (9)H bond acceptors: 1; (10)H bond donors: 0; (11)Freely Rotating Bonds: 4; (12)Polar Surface Area: 3.24 Å²; (13)Index of Refraction: 1.343; (14)Molar Refractivity: 39.07 cm³; (15)Molar Volume: 184.4 cm³; (16)Polarizability: 15.48×10^-24cm³; (17)Surface Tension: 18.1 dyne/cm; (18)Density: 1.209 g/cm³; (19)Flash Point: 23.8 °C; (20)Enthalpy of Vaporization: 35.41 kJ/mol; (21)Boiling Point: 115.7 °C at 760 mmHg; (22)Vapour Pressure: 18.8 mmHg at 25 °C.

Preparation of N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine: this chemical can be prepared by Diethylamine and 1,2-Dibromo-1,1,2,3,3,3-hexafluoro-propane.



This reaction needs NaH, Et₃N and Dimethylformamide at temperature of -5 °C. The reaction time is 6 hours. The yield is 21 %.

Uses of N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine: it can react with Propane-1,2-diol to get Diethyl-[4-methyl-2-(1,2,2,2-tetrafluoro-ethyl)-[1,3]dioxolan-2-yl]-amine.



This reaction needs Tetrahydrofuran at temperature of 50 °C for 3 hours. The yield is 54 %.

When you are using this chemical, please be cautious about it as the following: it is flammable which may cause burns. Please keep away from sources of ignition. And you should wear suitable protective clothing, gloves and eye/face protection when use it. Moreover, in case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And in case of accident or if you feel unwell, please seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
(1)SMILES:FC(F)(N(CC)CC)C(F)C(F)(F)F
(2)InChI:InChI=1/C7H11F6N/c1-3-14(4-2)7(12,13)5(8)6(9,10)11/h5H,3-4H2,1-2H3
(3)InChIKey:BNTFCVMJHBNJAR-UHFFFAOYAO
(4)Std. InChI:InChI=1S/C7H11F6N/c1-3-14(4-2)7(12,13)5(8)6(9,10)11/h5H,3-4H2,1-2H3
(5)Std. InChIKey:BNTFCVMJHBNJAR-UHFFFAOYSA-N