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2-Thiazolamine,N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)- (315703-52-7)

Identification
Name:2-Thiazolamine,N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-
Synonyms:JK184
CAS:315703-52-7
Molecular Formula: C19H18 N4 O S
Molecular Weight: 350.44
Molecular Structure: (C19H18N4OS) JK184
Properties
Density:1.3
Water Solubility:soluble to 100 mM in DMSO and to 25 mM in ethanol
Solubility:soluble to 100 mM in DMSO and to 25 mM in ethanol
Specification:

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine , with the CAS regitster number 315703-52-7, has the systematic name of N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-amine . And with the molecular formular of C19H18N4OS, it is also known to us as 2-Thiazolamine, N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)- ,JK184 and so on.

Properties of this kind of chemcial are as below: (1)ACD/LogP:  4.04 ; (2)ACD/LogD (pH 5.5):  4  ; (3)ACD/LogD (pH 7.4):  4.04  ; (4)ACD/BCF (pH 5.5):  630.65  ; (5)ACD/BCF (pH 7.4):  695.99  ; (6)ACD/KOC (pH 5.5):  3414.75  ; (7)ACD/KOC (pH 7.4):  3768.56  ; (8)#H bond acceptors:  5  ; (9)#H bond donors:  1  ; (10)#Freely Rotating Bonds:  4  ; (11)Polar Surface Area:  70.9  ; (12)Index of Refraction:  1.683  ; (13)Molar Refractivity:  101.86 cm3  ; (14)Molar Volume:  268.5 cm3 ; (15) Polarizability:  40.38 ×10-24cm3  ; (16)Surface Tension:  50.4 dyne/cm  ; (17)Density:  1.3 g/cm3.

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine is very active in biological field. Exhibits antiproliferative activity in a range of cancer cell lines (GI 50 = 3 - 21 nM) and in human xenografts in vivo .Inhibits alcohol dehydrogenase 7 (Adh7) (IC 50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro . Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC 50 = 30 nM). 

Besides, this kind of chemcial is soluble to 100 mM in DMSO and to 25 mM in ethanol and as to storage, you should conserve in an at +4°C. It has many suppliers around the world, such as Kouting Chemical Co., Ltd. 

And you could convert the following data information into the molecular structure:
SMILES: n1c(csc1Nc2ccc(OCC)cc2)c4c(nc3ccccn34)C
InChI: InChI=1/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22)
InChIKey: ROYXIPOUVGDTAO-UHFFFAOYAR 
 
 

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