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Serine,2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide (322-35-0)

Identification
Name:Serine,2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide
Synonyms:DL-Serine,2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide; Serine,2-(2,3,4-trihydroxybenzyl)hydrazide (7CI); Serine,2-(2,3,4-trihydroxybenzyl)hydrazide, DL- (8CI); Benserazide;DL-Seryltrihydroxybenzylhydrazine;N-(DL-Seryl)-N'-(2,3,4-trihydroxybenzyl)hydrazine;N1-(DL-Seryl)-N2-(2,3,4-trihydroxybenzyl)hydrazine; Serazide
CAS:322-35-0
Molecular Formula: C10H15 N3 O5
Molecular Weight: 257.24
InChI: InChI=1/C10H15N3O5/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16/h1-2,6,12,14-17H,3-4,11H2,(H,13,18)
Molecular Structure: (C10H15N3O5) DL-Serine,2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide; Serine,2-(2,3,4-trihydroxybenzyl)hydrazide (7...
Properties
Density:1.541 g/cm3
Refractive index:1.678
Specification:

 Benserazide ,its cas register number is 322-35-0. Benserazide (CAS NO.322-35-0) is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor, which is unable to cross the blood-brain barrier, and also can be called N-(DL-Seryl)-N'-(2,3,4-trihydroxybenzyl) Hydrazine ; 2-Amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanohydrazide ; DL-Serine 2-[(2,3,4-Trihydroxyphenyl)methyl] Hydrazide ; Benserazidum and Serazide .
 Benserazide (CAS NO.322-35-0) has little therapeutic effect on its own, and is only administered in combination with levodopa.Most levodopa is decarboxylated to dopamine before it reaches the brain, and since dopamine is unable to cross the blood-brain barrier, this translates to little therapeutic gain with strong peripheral side effects. Benserazide inhibits this decarboxylation.Adverse effects caused by peripheral dopamine. However, benserazide cannot reduce the centrally-mediated side effects of levodopa, particularly dyskinesia.

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