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8-Quinazolinecarboxamide,2-[(3,4-dichlorophenyl)amino]-3,4-dihydro-6-nitro-4-oxo-N-2-propen-1-yl- (331645-84-2)

Identification
Name:8-Quinazolinecarboxamide,2-[(3,4-dichlorophenyl)amino]-3,4-dihydro-6-nitro-4-oxo-N-2-propen-1-yl-
Synonyms:8-Quinazolinecarboxamide,2-[(3,4-dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl- (9CI)
CAS:331645-84-2
Molecular Formula: C18H13 Cl2 N5 O4
Molecular Weight: 434.23292
InChI: InChI=1/C18H13Cl2N5O4/c1-2-5-21-16(26)11-7-10(25(28)29)8-12-15(11)23-18(24-17(12)27)22-9-3-4-13(19)14(20)6-9/h2-4,6-8H,1,5H2,(H,21,26)(H2,22,23,24,27)
Molecular Structure: (C18H13Cl2N5O4) 8-Quinazolinecarboxamide,2-[(3,4-dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl- (9CI)
Properties
Flash Point: °C
Boiling Point: °Cat760mmHg
Density:1.58g/cm3
Refractive index:1.707
Biological Activity: Selective non-peptide inhibitor of caspase-3 (K i = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (K i > 10 μ M). Completely blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells (IC 50 = 14.9 μ M).
Flash Point: °C
Safety Data
 

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