Synonyms: | Pregna-1,4-diene-3,20-dione,6a,9-difluoro-11b,16a,17,21-tetrahydroxy-, cyclic 16,17-acetal withacetone, 21-acetate (7CI,8CI);Biscosal;Dermaplus;Flucinar;Fluocinolide acetate;Fluocinolone acetonide 21-acetate;Fluocinolone acetonide acetate;Lidex;Lidex E;Metosyn;NSC101791;Straderm;Topsym;Topsymin;Topsyn;Vanos; |
InChI: | InChI=1/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1 |
Specification: |
With CAS Registry Number 356-12-7, Fluocinonide is also can be named as 6alpha,9-Difluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone, 21-acetate ; Bestasone ; Biscosal ; Cortalar ; Fluocinolide acetate ; Fluocinolone acetonide 21-acetate ; Fluocinolone acetonide acetate , it belongs to the product category such as steroids. When heated to decomposition Fluocinonide emits toxic fumes of F-. Besides, Fluocinonide is poison by ingestion, subcutaneous, and intraperitoneal routes and very toxic if swallowed, so it is possible risk of harm to the unborn child. In case of accident, we should not breathe dust and avoid contact with eyes, wash immediately with plenty of soap-suds after contact with skin. We also can wear suitable protective clothing, gloves and eye/face protection. And if you feel unwell, seek medical advice immediately (show the label whenever possible.). In addition, Fluocinonide should be used with caution when treating children, pregnant women, nursing mothers, and anyone using the medication for longer than two weeks.
Fluocinonide is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema. It is also used in veterinary medicine and it is a treatment for allergies in dogs. Natural systemic cortisol concentrations can be suppressed for weeks after one week of topical exposure. Fluocinonide should not be used if infection is present. It should not be applied to the eyes or to sensitive areas such as the genitals or anus. Moreover, Fluocinonide should not be used if infection is present and not be applied to the eyes or to sensitive areas such as the genitals or anus. Fluocinonide ranks as a "high-potency" (second-highest rank) topical corticosteroid and minimal amounts should be used for a minimal length of time to avoid the occurrence of adverse effects.
The toxicity of Fluocinonide as following:
Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
guinea pig |
LD50 |
subcutaneous |
> 3170mg/kg (3170mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 694, 1982. |
mouse |
LD50 |
intraperitoneal |
160mg/kg (160mg/kg) |
|
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 17, Pg. 849, 1975. |
mouse |
LD50 |
oral |
> 6gm/kg (6000mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 386, 1975. |
mouse |
LD50 |
subcutaneous |
165mg/kg (165mg/kg) |
|
Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975. |
rat |
LD50 |
intraperitoneal |
300ug/kg (0.3mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 694, 1982. |
rat |
LD50 |
oral |
14mg/kg (14mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 694, 1982. |
rat |
LD50 |
subcutaneous |
720ug/kg (0.72mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 386, 1975. |
|