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6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline (356559-20-1)

Identification
Name:6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline
Synonyms:6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline;SB-525334
CAS:356559-20-1
Molecular Formula: C21H21N5
Molecular Weight: 0
InChI: InChI=1/C21H21N5/c1-13-6-5-7-16(24-13)19-18(25-20(26-19)21(2,3)4)14-8-9-15-17(12-14)23-11-10-22-15/h5-12,19H,1-4H3
Molecular Structure: (C21H21N5) 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline;SB-525334
Properties
Transport:UN 2811 6.1/PG 3
Flash Point: 265.453°C
Boiling Point: 515.314°C at 760 mmHg
Density:1.218g/cm3
Refractive index:1.661
Biological Activity: Selective inhibitor of transforming growth factor- β receptor I (ALK5, TGF- β RI) (IC 50 = 14.3 nM). Inhibits TGF- β 1-induced smad2/3 nuclear localisation and TGF- β 1-induced mRNA expression in kidney cells. Attenuates bleomycin-induced pulmonary fibrosis.
Flash Point: 265.453°C
Storage Temperature: 2-8°C
Safety Data
 

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