1,4,5,6,8-Pentaazaacenaphthylen-3-amine,1,5-dihydro-5-methyl-1-b-D-ribofuranosyl- (35943-35-2)

Identification
Name:	1,4,5,6,8-Pentaazaacenaphthylen-3-amine,1,5-dihydro-5-methyl-1-b-D-ribofuranosyl-
Synonyms:	6-Amino-4-methyl-8-(b-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine;API 2; NSC 154020; TCN; Triciribine
CAS:	35943-35-2
Molecular Formula:	C13H16 N6 O4
Molecular Weight:	320.35
InChI:	InChI=1/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)
Molecular Structure:
Properties
Flash Point:	388.3°C
Boiling Point:	718.5°Cat760mmHg
Density:	2.02g/cm³
Refractive index:	1.928
Biological Activity:	Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 β and AFX. In vitro, induces apoptosis and growth arrest preferentially in human cancer cells with elevated levels of Akt. In mice, potently and selectively inhibits growth of Akt-overexpressing tumors. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.
Flash Point:	388.3°C
Safety Data