| Identification |
| Name: | 2(1H)-Pyrimidinone,3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)- |
| Synonyms: | 1-(2-Hydroxyphenyl)-4-(3-nitrophenyl)-1,2,3,6-tetrahydropyrimidin-2-one;AG 3-5; Icilin |
| CAS: | 36945-98-9 |
| Molecular Formula: | C16H13 N3 O4 |
| Molecular Weight: | 311.29212 |
| InChI: | InChI=1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21) |
| Molecular Structure: |
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| Properties |
| Melting Point: | 200-208ºC |
| Flash Point: | 313.5 ºC |
| Boiling Point: | 594.8 ºC at 760 mmHg |
| Density: | 1.415 g/cm3 |
| Refractive index: | 1.672 |
| Water Solubility: | 0.1 mg/ml* at 25ºC in water.in DMSO: 15 mg/mL, soluble |
| Solubility: | 0.1 mg/ml* at 25ºC in water.in DMSO: 15 mg/mL, soluble |
| Appearance: | Light yellow solid. |
| Biological Activity: | Cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK-293 cells (EC 50 = 0.36 μ M) more potently than menthol or low temperatures. Produces "wet shakes" in vivo . |
| Flash Point: | 313.5 ºC |
| Color: | yellow |
| Safety Data |
| Hazard Symbols |
Xn: Harmful
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