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Butanamide,N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]- (37517-30-9)

Identification
Name:Butanamide,N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-
Synonyms:(+-)-3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide;(RS)-Acebutolol;Monitan;dl-Acebutolol;
CAS:37517-30-9
EINECS: 253-539-0
Molecular Formula: C18H28N2O4
Molecular Weight: 336.48
InChI: InChI=1/C18H28N2O4/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23)
Molecular Structure: (C18H28N2O4) (+-)-3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide;(RS)-Acebutolol;Monitan;dl-Acebu...
Properties
Melting Point: 119-123 ºC
Flash Point: 295°C
Boiling Point: 564.1°C at 760 mmHg
Density:1.118g/cm3
Stability:No data.
Refractive index:1.542
Water Solubility:259 MG/L
Solubility:259 mg/L
Appearance:Crystals.
Specification:

 Acebutolol ,its cas register number is 37517-30-9. It also can be called Prent ; Acetobutolol ; Neptal and Sectral . It is a beta blocker for the treatment of hypertension and arrhythmias. Acebutolol (CAS NO.37517-30-9) is a cardioselective beta blocker with ISA, and if a patient with Asthma bronchiale or chronic obstructive pulmonary disease (COPD) needs treatment with a beta blocker, it is therefore more suitable than non cardioselective beta blockers. It has no negative impact on serum lipids and works in hypertensive patients with high, normal, or low renin plasma concentrations, although acebutolol may be more efficient in patients with high or normal renin plasma concentrations. It is well absorbed from the GI tract and undergoes extensive hepatic metabolization resulting in the desbutyl amine acetolol which is readily converted into diacetolol. Altogether, 5 to 6% of all patients treated have to discontinue Acebutolol (CAS NO.37517-30-9) due to intolerable side effects.

Flash Point: 295°C
Storage Temperature: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Usage:Cardioselective ?adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II)
Safety Data
 

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