7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,3,6-dihydro-5-(2-propoxyphenyl)- (37762-06-4)

Identification
Name:	7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,3,6-dihydro-5-(2-propoxyphenyl)-
Synonyms:	7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,1,4-dihydro-5-(2-propoxyphenyl)- (9CI);2-(2-Propoxyphenyl)-8-aza-6-purinone;2-(o-Propoxyphenyl)-8-azapurin-6-one;8-Aza-2-(2-propoxyphenyl)-6-purinone;Mand B 22948;M&;B 22,948;Zaprinast;
CAS:	37762-06-4
EINECS:	253-655-1
Molecular Formula:	C13H13 N5 O2
Molecular Weight:	271.27462
InChI:	InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
Molecular Structure:
Properties
Density:	1.48 g/cm³
Refractive index:	1.718
Appearance:	White to off white powder
Specification:	Zaprinast ,its cas register number is 37762-06-4. It also can be called 1,4-Dihydro-5-(2-propoxyphenyl)-1,2,3-triazolo(4,5- d)pyrimidin-7-one ; 5-(2-Propoxyphenyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol ; and 2-o-Propoxyphenyl-8-azapurine-6-one .
Biological Activity:	Phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC 50 values are 0.15, 0.76, 12.0 and 29.0 μ M respectively).
Color:	white
Usage:	A selective inhibitor of cyclic-GMP phosphodiesterase (PDE V, calmodulin insensitive). Since cGMP mediates the vasorelaxant action of nitric oxide, as well as the natriuretic and diuretic effect of atrial natriuretic factor (ANF) through the activat
Safety Data
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