| Identification | |
| Name: | Benzeneacetic acid,3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]- |
| Synonyms: | GW 3965; GW3965A |
| CAS: | 405911-09-3 |
| Molecular Formula: | C33H31 Cl F3 N O3 |
| Molecular Weight: | 618.51 |
| InChI: | InChI=1/C33H31ClF3NO3.ClH/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26;/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40);1H |
| Molecular Structure: |  |
| Properties | |
| Flash Point: | 360.5°C |
| Boiling Point: | 672.4°Cat760mmHg |
| Density: | 1.261g/cm3 |
| Biological Activity: | Selective, orally active non-steroidal agonist for the liver X receptor (LXR). In cell-based reporter gene assays, acts as a full agonist of hLXR α and hLXR β (EC 50 values are 190 and 30 nM respectively). Up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis. |
| Flash Point: | 360.5°C |
| Safety Data | |
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