| Identification |
| Name: | 4-Thiazolidinecarboxylicacid, 2-[[4-[(4-nitrophenyl)methoxy]phenyl]methyl]-, ethyl ester |
| Synonyms: | SN 6; SN 6(pharmaceutical) |
| CAS: | 415697-08-4 |
| Molecular Formula: | C20H22 N2 O5 S |
| Molecular Weight: | 402.46 |
| InChI: | InChI=1/C20H22N2O5S/c1-2-26-20(23)18-13-28-19(21-18)11-14-5-9-17(10-6-14)27-12-15-3-7-16(8-4-15)22(24)25/h3-10,18-19,21H,2,11-13H2,1H3 |
| Molecular Structure: |
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| Properties |
| Flash Point: | 305.3°C |
| Boiling Point: | 581.2°Cat760mmHg |
| Density: | 1.285g/cm3 |
| Refractive index: | 1.605 |
| Biological Activity: | Selective Na + /Ca 2+ -exchange (NCX) inhibitor; displays some selectivity for NCX1. IC 50 values are 2.9, 16 and 8.6 μ M for inhibition of intracellular Na+-dependent 45 Ca 2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC 50 = 18 μ M) but minimal activity against NCKX2 and various receptors and ion channels (IC 50 > 30 μ M). Preferentially blocks Ca 2+ influx mode and is more selective for NCX isoforms than KB-R7943 (2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate ). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC 50 = 0.63 μ M). |
| Flash Point: | 305.3°C |
| Safety Data |
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