5H-Imidazo[2,1-i]purin-5-one,8-ethyl-3,4,7,8-tetrahydro-4-methyl-2-phenyl-, (8R)- (444717-56-0)

Identification
Name:	5H-Imidazo[2,1-i]purin-5-one,8-ethyl-3,4,7,8-tetrahydro-4-methyl-2-phenyl-, (8R)-
Synonyms:	5H-Imidazo[2,1-i]purin-5-one,8-ethyl-1,4,7,8-tetrahydro-4-methyl-2-phenyl-, (8R)- (9CI); PSB 11
CAS:	444717-56-0
Molecular Formula:	C16H17 N5 O
Molecular Weight:	295.34
InChI:	InChI=1/C16H17N5O.ClH/c1-3-11-9-21-15(17-11)12-14(20(2)16(21)22)19-13(18-12)10-7-5-4-6-8-10;/h4-8,11H,3,9H2,1-2H3,(H,18,19);1H/t11-;/m1./s1
Molecular Structure:
Properties
Flash Point:	292.5°C
Boiling Point:	560.1°C at 760 mmHg
Biological Activity:	Potent and selective antagonist for the human adenosine A 3 receptor, with low affinity for the rat A 3 receptor (K i values are 2.3 and > 10000 nM respectively). Displays > 1000-fold selectivity over human A 1 and A 2A receptors (K i values are 4.1 and 3.3 μ M respectively) and > 180-fold selectivity over rat A 1 , rat A 2A and mouse A 2B receptors. Acts as an inverse agonist in the [ 35 S]GTP γ S binding assay in hA 3 -CHO cells (IC 50 = 36 nM).
Flash Point:	292.5°C
Safety Data