| Identification | ||
| Name: | Azathioprine | |
| Synonyms: | 1H-Purine,6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]- (9CI);Purine,6-[(1-methyl-4-nitroimidazol-5-yl)thio]- (6CI,8CI);6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine;6-(1-Methyl-4-nitromidazol-5-ylthio)purine;Azamune;Azanin;Azathioprin;Azoran;BW 57-322;Imuran;Imurek;Imurel;Muran;NSC 39084; | |
| CAS: | 446-86-6 | |
| EINECS: | 207-175-4 | |
| Molecular Formula: | C9H7N7O2S | |
| Molecular Weight: | 277.26 | |
| InChI: | InChI=1/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13) | |
| Molecular Structure: | ![(C9H7N7O2S) 1H-Purine,6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]- (9CI);Purine,6-[(1-methyl-4-nitroimidazol-5-y...](https://img.guidechem.com/casimg/446-86-6.gif) |
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| Properties | ||
| Density: | 1.9 g/cm3 | |
| Stability: | Stable. Incompatible with strong oxidizing agents, strong bases. | |
| Refractive index: | 1.923 | |
| Water Solubility: | <0.1 g/100 mL at 23 ºC | |
| Solubility: | Soluble | |
| Appearance: | Light-yellow crystalline powder | |
| Specification: |
Azathioprine (CAS NO.446-86-6) is also named as 6-((1-Methyl-4-nitro-1h-imidazol-5-yl)thio)-1h-purin ; 6-((1-Methyl-4-nitroimidazol-5-yl)thio)-purin ; 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine ; 6-(1-Methyl-4-nitro-5-imidazolythio)-9H-pur-ine ; 6-(1-Methyl-4-nitroimidazol-5-ylthio)purin ; 6-(1-Methyl-p-nitro-5-imidazolyl)-thiopurine ; Azamun and so on. | |
| Report: |
NTP 10th Report on Carcinogens. IARC Cancer Review: Group 1 IMEMDT ?? IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 119.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.:?) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Sufficient Evidence IMEMDT ?? IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 (1981),p. 47.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.:?) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT ?? IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 (1981),p. 47.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.:?) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Studies (ipr); No Evidence: rat CANCAR ?? Cancer. 40 (1977),1935. ; Clear Evidence: mouse CANCAR ?? Cancer. 40 (1977),1935. . EPA Genetic Toxicology Program. | |
| Storage Temperature: | Freezer | |
| Color: | Pale yellow crystals from 50% aq acetone | |
| Usage: | An immunosuppressive antimetabolite. Also active as disease modifying antirheumatic drug (DMARD) | |
| Safety Data | ||
| Hazard Symbols | ||
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