Isoquinoline,5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methyl- (451462-58-1)

Identification
Name:	Isoquinoline,5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methyl-
Synonyms:	1H-1,4-Diazepine,hexahydro-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-, (2S)- (9CI); H 1152
CAS:	451462-58-1
Molecular Formula:	C16H21 N3 O2 S
Molecular Weight:	319.42
Molecular Structure:
Properties
Biological Activity:	Rho-kinase (ROCK) inhibitor that displays high selectivity over other protein kinases (IC 50 values are 0.012, 0.180, 0.360, 0.745, 3.03, 5.68 and 28.3 μ M for ROCKII, CAMKII, PKG, Aurora A, PKA, PKC and MLCK respectively). Inhibits sulprostone-induced contractions in guinea pig aorta (IC 50 = 190 nM) and displays proerectile effects in rats.
Safety Data

Other Product

Isoquinoline,5-[(hexahydro-3-methyl-1H-1,4-diazepin-1-yl)sulfonyl]-
Acetamide,N-[2-[(3-fluorophenyl)sulfonyl]-5-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)phenyl]-, monohydrochloride
Propanamide,2-amino-N-(hexahydro-4-methyl-5-oxo-1-phenyl-1H-1,4-diazepin-6-yl)-,(2S)-
Benzonitrile,2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-
Benzenemethanol,2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-
Benzenemethanamine,2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-
Benzaldehyde,2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-
1H-PYRROLE-2-CARBOXYLIC ACID, 5-[[HEXAHYDRO-4-[4-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1H-1,4-DIAZEPIN-1-YL]SULFONYL]-1-METHYL-, METHYL ESTER
Boronic acid,[4-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)sulfonyl]phenyl]-
Benzenamine,2-[(3-fluorophenyl)sulfonyl]-5-(hexahydro-1H-1,4-diazepin-1-yl)-N-methyl-, monohydrochloride
Isoquinoline,1-chloro-5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-
3-Pyridinecarbonitrile,5-[[2-(4-cyano-1-naphthalenyl)hexahydro-1H-1,2-diazepin-1-yl]methyl]-
Isoquinoline,5-[[hexahydro-6-(phenylmethyl)-1H-1,4-diazepin-1-yl]sulfonyl]-
Benzonitrile,4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-
Benzaldehyde,4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-
Benzenemethanamine,4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-
Benzenemethanol,4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-
1-Naphthalenecarbonitrile,4-[2-[[1-(1,1-dimethylethyl)-5-methyl-1H-pyrazol-3-yl]methyl]hexahydro-1H-1,2-diazepin-1-yl]-
Benzonitrile, 4-[(hexahydro-1H-1,4-diazepin-1-yl)methyl]-
1-Naphthalenecarbonitrile,4-[hexahydro-2-[(1-phenyl-1H-pyrazol-5-yl)methyl]-1H-1,2-diazepin-1-yl]-