| Identification | |
| Name: | 4H-1-Benzopyran-4-one,5,6,7-trihydroxy-2-phenyl- |
| Synonyms: | Baicalein(6CI);Flavone, 5,6,7-trihydroxy- (7CI,8CI);5,6,7-Trihydroxyflavone;Baikalein;NSC 661431;Noroxylin; |
| CAS: | 491-67-8 |
| Molecular Formula: | C15H10O5 |
| Molecular Weight: | 270.2369 |
| InChI: | InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H |
| Molecular Structure: |  |
| Properties | |
| Density: | 1.548 g/cm3 |
| Water Solubility: | Soluble to 50 mM in DMSO |
| Solubility: | Soluble to 50 mM in DMSO |
| Appearance: | Yellow Crystalline Solid |
| Specification: | Yellow Crystalline Solid usageEng:An inhibitor of 12-lipoxygenase, leukotriene biosynthesis and release of lysosomal enzymes. It also inhibits cellular Ca2+ uptake and mobilization and adjuvant-induced arthritis. Baicalein is the flavonoid component of Nepalese and Sino-Japanese crude d Safety Statements:26-36 26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 36:Wear suitable protective clothing |
| Biological Activity: | Inhibitor of 5- and platelet 12-lipoxygenases (IC 50 values are 9.5 and 0.12 mM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Anti-inflammatory in vivo . |
| Usage: | An inhibitor of 12-lipoxygenase, leukotriene biosynthesis and release of lysosomal enzymes. It also inhibits cellular Ca2+ uptake and mobilization and adjuvant-induced arthritis. Baicalein is the flavonoid component of Nepalese and Sino-Japanese crude d |
| Safety Data | |
| Hazard Symbols |
Xi: Irritant
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