| Identification | |
| Name: | 1-Piperidinebutanol, a-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)- |
| CAS: | 50679-08-8 |
| EINECS: | 256-710-8 |
| Molecular Formula: | C32H41 N O2 |
| Molecular Weight: | 471.74 |
| InChI: | InChI=1/C32H41NO2/c1-31(2,3)26-18-16-25(17-19-26)30(34)15-10-22-33-23-20-29(21-24-33)32(35,27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-14,16-19,29-30,34-35H,10,15,20-24H2,1-3H3/p+1/t30-/m1/s1 |
| Molecular Structure: |  |
| Properties | |
| Density: | 1.088 g/cm3 |
| Stability: | No data. |
| Water Solubility: | 0.001 G/100 ML (30 ºC) |
| Solubility: | Very slightly soluble in cold water. |
| Appearance: | Solid. (Solid crystalline powder.) |
| Biological Activity: | Histamine H 1 receptor antagonist. Also blocks hERG and K ATP channels (IC 50 values are 204 nM and 1.2 μ M respectively). Inhibits the delayed rectifier K + current (I Kr ) in guinea pig ventricular myocytes (IC 50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo . |
| Storage Temperature: | 2-8°C |
| Color: | White to off-white crystalline powder Crystals from acetone |
| Usage: | Nonsedating-type histamine H1-receptor antagonist. Antihistaminic |
| Safety Data | |
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