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Benzamide,4-amino-N-[2-(diethylamino)ethyl]- (51-06-9)

Identification
Name:Benzamide,4-amino-N-[2-(diethylamino)ethyl]-
Synonyms:Benzamide,p-amino-N-[2-(diethylamino)ethyl]- (8CI);4-Amino-N-(diethylaminoethyl)benzamide; 4-Amino-N-[2-(diethylamino)ethyl]benzamide;N-(2-(Diethylamino)ethyl)-4-aminobenzamide; NSC 27461; Novocainamid;Novocainamide; Novocaine amide; Novocamid; Procainamide; Procaine amide;Procanbid; SP 100; SP 100 (pharmaceutical);p-Amino-N-(2-diethylaminoethyl)benzamide; p-Aminobenzoic diethylaminoethylamide
CAS:51-06-9
EINECS: 200-078-8
Molecular Formula: C13H21 N3 O
Molecular Weight: 235.37
InChI: InChI=1/C13H21N3O/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17)
Molecular Structure: (C13H21N3O) Benzamide,p-amino-N-[2-(diethylamino)ethyl]- (8CI);4-Amino-N-(diethylaminoethyl)benzamide; 4-Amino-N...
Properties
Flash Point: 208.9°C
Boiling Point: 421.8°Cat760mmHg
Density:1.060
Specification:

Administration:Procainamide is administered intravenously or orally. When administered intravenously, a loading dose should first be given, though care should be taken not to cause hypotension. Procainamide's active metabolite is N-acetyl procainamide, which is stronger than procainamide and excreted by the kidneys and the renal system. Loading dose is 100mg IV bolus given slowly over 5 minutes. Max dose is 17mg/kg. Use is discontinued when dysrhythmia is suppressed, or if hypotension ensues, QRS complex widens by 50% or more, or maximum dose is achieved.
Side effects:Adverse effects include rash, myalgia, hypersensitivity reactions (fever, agranulocytosis), Drug-Induced Lupus Erythematosus (particularly in slow-acetylators), and proarrhythmic effects (e.g., torsades de pointes). Treatment with procainamide can cause antibody production against cellular components, accounting for the systemic lupus erythematosus-like adverse reactions

Flash Point: 208.9°C
Safety Data
 

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