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2-Oxazolamine,N-(dicyclopropylmethyl)-4,5-dihydro- (54187-04-1)

Identification
Name:2-Oxazolamine,N-(dicyclopropylmethyl)-4,5-dihydro-
Synonyms:NSC 664312;Oxaminozoline;Rilmenidene;Rilmenidine;S 3341;
CAS:54187-04-1
EINECS: 259-021-0
Molecular Formula: C10H16N2O
Molecular Weight: 180.24684
InChI: InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Molecular Structure: (C10H16N2O) NSC 664312;Oxaminozoline;Rilmenidene;Rilmenidine;S 3341;
Properties
Melting Point: 106 - 107
Density:1.45 g/cm3
Stability:Stable at normal temperatures and pressures.
Water Solubility:H2O: 7.3 mg/mL in water
Solubility:H2O: 7.3 mg/mL in water
Appearance:solid
Specification:

Side effects of Rilmenidine (54187-04-1):
1.At a dose of 1 mg given as a single daily administration during controlled trials, the incidence of side effects was comparable to that observed with placebo.
2.At a dose of 2 mg per day of rilmenidine, controlled comparative studies versus clonidine (0.15 to 0.30 mg/day) or alpha2-methyldopa (500 to 1000 mg/day) demonstrated that the incidence of side effects was significantly lower with rilmenidine than with either clonidine or a-methyldopa.
Side-effects are rare, non-severe, and transient at therapeutic doses: asthenia, palpitations, insomnia, drowsiness, fatigue on exercise, epigastric pain, dryness of the mouth, diarrhea, skin rash; and exceptionally, cold extremities, postural hypotension, sexual disorders, anxiety, depression, pruritus, edema, cramps, nausea, constipation, hot flushes

 

Biological Activity: I 1 -imidazoline binding site selective ligand and α 2 -adrenoceptor agonist. Possesses greater I 1 vs α 2 selectivity than the prototypical compound, clonidine.
Storage Temperature: Keep tightly closed.
Color: white
Usage:Selective i1 imidazoline receptor agonist.
Safety Data
 

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