| Identification | |
| Name: | Domperidone |
| Synonyms: | 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone;Domperidonum;Motilium; |
| CAS: | 57808-66-9 |
| EINECS: | 260-968-7 |
| Molecular Formula: | C22 H24 Cl N5 O2 |
| Molecular Weight: | 425.91126 |
| InChI: | InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30) |
| Molecular Structure: |  |
| Properties | |
| Melting Point: | 242.5 oC |
| Density: | 1.341 g/cm3 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| Water Solubility: | DMSO: >10 mg/mL |
| Solubility: | DMSO: >10 mg/mL |
| Appearance: | white powder |
| Specification: |
? Domperidone (CAS NO.57808-66-9), its Synonyms are 2H-Benzimidazol-2-one, 1,3-dihydro-5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)- ; 2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro- ; 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone ; Domperidonum ; Motilium . It is white powder. |
| Biological Activity: | Peripheral dopamine D 2 -like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED 50 values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively). |
| Storage Temperature: | Keep tightly closed. |
| Color: | white |
| Usage: | Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. |
| Safety Data | |
| Hazard Symbols |
Xn:Harmful
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