| Identification | |
| Name: | 2H-Benzo[a]quinolizin-2-one,1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (3R,11bR)-rel- |
| CAS: | 58-46-8 |
| EINECS: | 200-383-6 |
| Molecular Formula: | C19H27 N O3 |
| Molecular Weight: | 317.47 |
| InChI: | InChI=1/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3 |
| Molecular Structure: | ![(C19H27NO3) 2H-Benzo[a]quinolizin-2-one,1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- (6CI,8CI);2H-Benzo[a]...](https://img1.guidechem.com/chem/e/dict/23/58-46-8.jpg) |
| Properties | |
| Transport: | 3249 |
| Melting Point: | 128-130?C |
| Flash Point: | 225.3°C |
| Boiling Point: | 448.9°Cat760mmHg |
| Density: | 1.12 |
| Refractive index: | 1.554 |
| Appearance: | white to off-white solid |
| Specification: |
Tetrabenazine ,its CAS NO. is 58-46-8,the synonyms is (3r,11br)-Rel-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2h-benzo[a]quinolizin-2-one ; Tetrabenazine ; 2h-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (3r,11br)-rel- ; 9,10-Dimethoxy-1,3,4,6,7,11b-hexahydro-3-isobutyl-2h-benzo[a]quinolizin-2-one;1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2h-benzo[a]quinolizin-2-one ; Nitoman ; Ro 1-9569 ; Rubigen . |
| Packinggroup: | III |
| Biological Activity: | Potent inhibitor of vesicular monoamine uptake; depletes stores of dopamine, serotonin and noradrenalin. Binds with high affinity (IC 50 = 3.2 nM) to vesicular monoamine transporter (VMAT) in chromaffin granule membranes and displays higher affinity for VMAT2 than VMAT1. Also reported to block dopamine receptors. Causes behavioral depression; inhibits locomotor activity and produces hypothermia upon systemic administration in rats and mice. |
| Flash Point: | 225.3°C |
| Storage Temperature: | 2-8°C |
| Usage: | Dopamine depleting agent. An antidyskinetic; antipsychotic. |
| Safety Data | |
| Hazard Symbols |
Xn: Harmful
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