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Butorphanol tartrate (58786-99-5)

Identification
Name:Butorphanol tartrate
Synonyms:Butorphanol tartrate (JAN/USP);Morphinan-3,14-diol,17-(cyclobutylmethyl)-,(2S,3S)-2,3-dihydroxybutanedioate (1:1) (salt);Stadol;Moradol;Stadol (TN);
CAS:58786-99-5
EINECS: 261-443-5
Molecular Formula: C21H29NO2.C4H6O6
Molecular Weight: 477.61
InChI: InChI=1/C21H29NO2.C4H6O6/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15;5-1(3(7)8)2(6)4(9)10/h6-7,13,15,19,23-24H,1-5,8-12,14H2;1-2,5-6H,(H,7,8)(H,9,10)/t19-,20+,21-;1-,2-/m10/s1
Molecular Structure: (C21H29NO2.C4H6O6) Butorphanol tartrate (JAN/USP);Morphinan-3,14-diol,17-(cyclobutylmethyl)-,(2S,3S)-2,3-dihydroxybutan...
Properties
Transport:1544
Density:g/cm3
Specification:

To protect yourself, you can put on eyeshields, faceshields, full-face particle respirator type N100 (US), gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges.
It exhibits partial agonist and antagonist activity at the μ opioid receptor and agonist activity at the κ opioid receptor. Stimulation of these receptors on central nervous system neurons causes an intracellular inhibition of adenylate cyclase, closing of influx membrane calcium channels, and opening of membrane potassium channels. This leads to hyperpolarization of the cell membrane potential and suppression of action potential transmission of ascending pain pathways. Because of its κ-agonist activity, at analgesic doses butorphanol increases pulmonary arterial pressure and cardiac work. Additionally, κ-agonism can cause dysphoria at therapeutic or supertherapeutic doses; this gives butorphanol a lower potential for abuse than other opioid drugs.

Packinggroup: II
Safety Data
Hazard Symbols Xn: Harmful
 

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