Identification |
Name: | 2,4-Heptadienamide,7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)- |
Synonyms: | 2,4-Heptadienamide,7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, [R-(E,E)]-;(R)-Trichostatin A;TSA;Trichostatin A; |
CAS: | 58880-19-6 |
Molecular Formula: | C17H22N2O3 |
Molecular Weight: | 302.36818 |
InChI: | InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1 |
Molecular Structure: |
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Properties |
Density: | 1.139 g/cm3 |
Refractive index: | 136 ° (C=0.3, MeOH) |
Water Solubility: | Soluble in ethanol: 1 mg/mL |
Solubility: | Soluble in ethanol: 1 mg/mL |
Appearance: | Off-white powder |
Specification: | Safety Statements:26-36 26:In case of contact with eyes, rinse immediately with plenty
of water and seek medical advice 36:Wear suitable protective clothing |
Biological Activity: | Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. |
Storage Temperature: | −20°C |
Safety Data |
Hazard Symbols |
Xn: Harmful
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