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5-Isobenzofurancarbonitrile,1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro- (59729-33-8)

Identification
Name:5-Isobenzofurancarbonitrile,1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-
Synonyms:1-(3-Dimethylaminopropyl)-1-(4-fluorophenyl)-5-cyanophthalan;1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile;Bonitrile;Lu 10-171;Nitalapram;
CAS:59729-33-8
EINECS: 261-891-1
Molecular Formula: C20H21FN2O
Molecular Weight: 324.391943
InChI: InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3
Molecular Structure: (C20H21FN2O) 1-(3-Dimethylaminopropyl)-1-(4-fluorophenyl)-5-cyanophthalan;1-[3-(Dimethylamino)propyl]-1-(4-fluoro...
Properties
Transport:25kgs
Melting Point: 180 - 187 C
Flash Point: 212.8oC
Boiling Point: 428.3oC at 760 mmHg
Density:1.18 g/cm3
Stability:Stable at normal temperatures and pressures.
Water Solubility:SOLVENT
Solubility:SOLVENT
Appearance:white to off-white crystalline powder
Specification:

? Citalopram (CAS NO.59729-33-8) is generally considered safe and well-tolerated in the therapeutic dose range of 10 to 60 mg/day (a dose of 60 mg/day is reserved for patients who do not respond to lower doses). A doctor must always monitor a patient taking an SSRI such as citalopram. Distinct from some other agents in its class, citalopram exhibits linear pharmacokinetics and minimal drug interaction potential, making it a better choice for the elderly or comorbid patients.
Citalopram can have a number of adverse effects. In clinical trials, over 10% of patients reported one or more of the following side effects: fatigue, drowsiness, dry mouth, increased sweating (hyperhidrosis), trembling, headache, dizziness, sleep disturbances, insomnia, cardiac arrhythmia, hallucinations, blood pressure changes, nausea and/or vomiting, diarrhea, heightened anorgasmia in females, impotence and ejaculatory problems in males. In rare cases (around over 1% of cases), some allergic reactions, convulsions, mood swings, anxiety and confusion have been reported. Also sedation may be present during treatment of citalopram. If this occurs it is advisable to take the dose at bedtime instead of in the morning.[citation needed]

Packinggroup: III
Biological Activity: Highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake (IC 50 values are 1.8, 8800 and 41000 nM respectively). Has negligible activity at a wide range of receptors and is clinically used as an antidepressant. Also available as part of the Serotonin Uptake Inhibitor Tocriset? .
Flash Point: 212.8oC
Storage Temperature: Keep tightly closed. Store at 2-8 C
Usage:

Selective serotonin uptake inhibitor. Antidepressant.

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