| Identification |
| Name: | 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN |
| Synonyms: | JLK6;GAMMA-SECRETASE INHIBITOR XI;7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN |
| CAS: | 62252-26-0 |
| Molecular Formula: | C10H8ClNO3 |
| Molecular Weight: | 225.63 |
| InChI: | InChI=1/C10H8ClNO3/c1-14-10-8(11)6-3-2-5(12)4-7(6)9(13)15-10/h2-4H,12H2,1H3 |
| Molecular Structure: |
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| Properties |
| Flash Point: | 229.7°C |
| Boiling Point: | 456.1°C at 760 mmHg |
| Density: | 1.46g/cm3 |
| Refractive index: | 1.628 |
| Biological Activity: | Inhibitor of γ -secretase that selectively inhibits β APP cleavage without affecting other γ -secretase-mediated pathways. Prevents recovery of A β 40 and A β 42 from HEK293 cell overexpressing wild-type or Swedish-mutated β APP (IC 50 ~ 30 μ M) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α -secretase, the proteosome or GSK3 β . |
| Flash Point: | 229.7°C |
| Storage Temperature: | Store at RT |
| Safety Data |
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