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2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE (627536-09-8)

Identification
Name:2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE
Synonyms:SD-208;2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE
CAS:627536-09-8
Molecular Formula: C17H10ClFN6
Molecular Weight: 352.7529032
InChI: InChI=1/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)
Molecular Structure: (C17H10ClFN6) SD-208;2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE
Properties
Flash Point: 232.2°C
Boiling Point: 460.4°C at 760 mmHg
Density:1.487g/cm3
Refractive index:1.717
Biological Activity: Potent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.
Flash Point: 232.2°C
Storage Temperature: 2-8°C
Safety Data
 

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