| Identification |
| Name: | AEG 3482 |
| Synonyms: | 6-PHENYL-IMIDAZO[2,1-B][1,3,4]THIADIAZOLE-2-SULFONIC ACID AMIDE;6-PHENYLIMIDAZO[2,1-B]-1,3,4-THIADIAZOLE-2-SULFONAMIDE;AEG 3482;IMIDAZO[2,1-B]-1,3,4-THIADIAZOLE-2-SULFONAMIDE, 6-PHENYL- |
| CAS: | 63735-71-7 |
| Molecular Formula: | C10H8N4O2S2 |
| Molecular Weight: | 0 |
| InChI: | InChI=1/C10H8N4O2S2/c11-18(15,16)10-13-14-6-8(12-9(14)17-10)7-4-2-1-3-5-7/h1-6H,(H2,11,15,16) |
| Molecular Structure: |
![(C10H8N4O2S2) 6-PHENYL-IMIDAZO[2,1-B][1,3,4]THIADIAZOLE-2-SULFONIC ACID AMIDE;6-PHENYLIMIDAZO[2,1-B]-1,3,4-THIADIA...](https://img.guidechem.com/structure/63735-71-7.gif) |
| Properties |
| Density: | 1.75g/cm3 |
| Refractive index: | 1.834 |
| Biological Activity: | Inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC 50 = 20 μ M). |
| Storage Temperature: | Store at RT |
| Safety Data |
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