| Identification | |
| Name: | Colchicine |
| Synonyms: | Acetamide,N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-;Colchicine (8CI); Benzo[a]heptalene, acetamide deriv.; (-)-Colchicine;(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide;Colchineos; Colchisol; Colcin; Colsaloid; Condylon; NSC 757 |
| CAS: | 64-86-8 |
| EINECS: | 200-598-5 |
| Molecular Formula: | C22H25NO6 |
| Molecular Weight: | 399.44 |
| InChI: | InChI=1/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1 |
| Molecular Structure: | ![(C22H25NO6) Acetamide,N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-;Colchicine ...](https://img.guidechem.com/casimg/64-86-8.gif) |
| Properties | |
| Transport: | UN 1544 |
| Flash Point: | 392.9°C |
| Boiling Point: | RELATIVE DENSITY |
| Density: | 1.32 g/cm3 |
| Stability: | Stable. Light sensitive. Incompatible with strong oxidizing agents. |
| Refractive index: | 1.584 |
| Alpha: | -250 o (C=1, ALCOHOL) |
| Solubility: | |
| Appearance: | yellow powder |
| Specification: |
? Colchicine (CAS NO.64-86-8), its Synonyms are 7-alpha-H-Colchicine ; 7alphaH-Colchicine ; AI3-31149 ; Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)- ; Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy- ; Acetamide, N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)- ; Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)- . It is odorless or nearly odorless pale yellow needles or powder that darkens on exposure to light. |
| Report: |
EPA Extremely Hazardous Substances List. EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory. |
| Packinggroup: | I |
| Biological Activity: | Plant-derived alkaloid that binds to tubulin and depolymerizes microtubules. |
| Flash Point: | 392.9°C |
| Storage Temperature: | Poison room |
| Sensitive: | Light Sensitive |
| Color: | white to yellow with a green cast |
| Usage: | An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signal |
| Safety Data | |
| Hazard Symbols |
T+:Verytoxic
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