| Identification | |
| Name: | Nilotinib |
| Synonyms: | 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide;4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl]benzamide;AMN-107;AMN107;Benzamide, 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-(3-pyridinyl)-2-pyrimidinyl)amino)-;AMN 107;Nilotinib(TINIBS );Nilotinib & its intermediates;Nilotinib hydrochloride monohydrate; |
| CAS: | 641571-10-0 |
| Molecular Formula: | C28H22F3N7O |
| Molecular Weight: | 529.52 |
| InChI: | InChI=1/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37) |
| Molecular Structure: | ![(C28H22F3N7O) 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)am...](https://img.guidechem.com/casimg/641571-10-0.jpg) |
| Properties | |
| Density: | 1.36 g/cm3 |
| Refractive index: | 1.65 |
| Appearance: | Off-White Solid |
| Specification: |
?Nilotinib , its cas register number 641571-10-0. It also can be called?AMN 107 ; AMN107 ; Nilotinib ; 4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide ; Tasigna ; and UNII-F41401512X .?Its classification code are Antineoplastic and Antineoplastic Agents . |
| Usage: | Nilotinib (CAS NO.641571-10-0) is used in treatment of leukemia (specifically chronic myeloid leukemia). In that study 92% of patients (already resistant or unresponsive to Gleevec) achieved a normal white blood cell counts after five months of treatment. The drug carries a black box warning for possible heart complications. |
| Safety Data | |
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