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Ethanone,1-(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl- (64285-06-9)

Identification
Name:Ethanone,1-(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl-
Synonyms:Ethanone,1-(9-azabicyclo[4.2.1]non-2-en-2-yl)-, (1R)-; 9-Azabicyclo[4.2.1]nonane,ethanone deriv.; (+)-Anatoxin a; (+)-Anatoxin a; (+)-Anatoxin-a; Anatoxin I; Anatoxin a; Anatoxin a
CAS:64285-06-9
Molecular Formula: C10H15 N O
Molecular Weight: 165.2322
InChI: InChI=1S/C10H15NO/c1-7(12)9-4-2-3-8-5-6-10(9)11-8/h4,8,10-11H,2-3,5-6H2,1H3/t8-,10-/m1/s1
Molecular Structure: (C10H15NO) Ethanone,1-(9-azabicyclo[4.2.1]non-2-en-2-yl)-, (1R)-; 9-Azabicyclo[4.2.1]nonane,ethanone deriv.; (+...
Properties
Density:1.037 g/cm3
Refractive index:1.503
Water Solubility:Soluble to 50 mM in Water
Solubility:Soluble to 50 mM in Water
Appearance:Lyophilized Solid
Specification:

Category: Toxic Substances
Toxicity classification: highly toxic
Acute toxicity: abdominal - mice LDL0: 0.25 mg / kg
Flammable hazardous characteristics: flammable; burning of toxic nitrogen oxide fumes
Storage features: Treasury ventilation, low temperature, dry
Fire-extinguishing agents: water, carbon dioxide, dry powder, sand

Biological Activity: A potent nicotinic agonist (K i values are 1.25 and 1840 nM for α 4 β 2 and α 7 nicotinic receptors respectively). Stimulates [ 3 H]-dopamine release from rat striatal synaptosomes (EC 50 = 136 nM).
Color: Oil
Usage:(+)-Anatoxin-a is a secondary, bicyclic amine alkaloid and cyanotoxin with acute neurotoxicity. The toxin is produced by at least four different genera of cyanobacteria and has been reported in North America, Europe, Africa, Asia, and New Zealand. Symptoms of anatoxin exposure are loss of coordination, muscular fasciculations, convulsions and death by respiratory paralysis.
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