Specification: |
The Sulfameter ,its cas register number is 651-06-9.It also can be called as Sulfametoxydiazine and the IUPAC name about this chemical is 4-Amino-N-(5-methoxypyrimidin-2-yl)benzenesulfonamide .It belongs to the following product categories, such as Intermediates & Fine Chemicals, Pharmaceuticals, Sulfur & Selenium Compounds and so on. Also, it can be stored between 2°C and 8°C. It slightly soluble in water.
The Sulfameter is crystalline solid and is a long-acting sulfonamide antibacterial. It can be used as a leprostatic agent and in the treatment of urinary tract infections.Also, it has long acting sulfonamide used in leprosy, urinary, and respiratory tract infections. It is a dangerous chemical, because it irritating to eyes, respiratory system and skin. In the using process, you need to wear suitable protective clothing and in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Except these safety informations, there are also exist other data like WGK Germany is 2 and RTECS about this chemical is WP0525000.
Following are the chemical properties about Sulfameter :(1)#H bond acceptors: 7 ; (2)#H bond donors: 3 ; (3)#Freely Rotating Bonds: 3 ; (4)Polar Surface Area: 84.01Å2 ; (5)Index of Refraction: 1.646 ; (6)Molar Refractivity: 69.51 cm3 ; (7)Molar Volume: 191.2 cm3 ; (8)Polarizability: 27.55x10-24cm3 ; (9)Surface Tension: 75 dyne/cm; (10)Enthalpy of Vaporization: 81.68 kJ/mol ; (11)Vapour Pressure: 1.05E-11 mmHg at 25°C
This chemical can be described computed from structure:
(1)Canonical SMILES: COC1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
(2)InChI: InChI=1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
(3)InChIKey: GPTONYMQFTZPKC-UHFFFAOYSA-N
The most important thing about Sulfameter is the toxicity, following is the form:
Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
cat |
LD50 |
oral |
1gm/kg (1000mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 695, 1961. |
dog |
LD50 |
oral |
1gm/kg (1000mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 695, 1961. |
guinea pig |
LD50 |
oral |
2500mg/kg (2500mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 695, 1961. |
mouse |
LD50 |
intraperitoneal |
3100mg/kg (3100mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 695, 1961. |
mouse |
LD50 |
intravenous |
1gm/kg (1000mg/kg) |
|
"Experimental Chemotherapy, Volume II," Schnitzer, R.J., and F. Hawking, eds. Academic Press New York, 1964Vol. 2, Pg. 249, 1964. |
mouse |
LD50 |
oral |
16gm/kg (16000mg/kg) |
|
Biochemical Pharmacology. Vol. 16, Pg. 1367, 1967. |
mouse |
LD50 |
subcutaneous |
2500mg/kg (2500mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 695, 1961. |
rabbit |
LD50 |
intravenous |
100mg/kg (100mg/kg) |
|
"Experimental Chemotherapy, Volume II," Schnitzer, R.J., and F. Hawking, eds. Academic Press New York, 1964Vol. 2, Pg. 249, 1964. |
rat |
LD50 |
intraperitoneal |
2300mg/kg (2300mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 695, 1961. |
rat |
LD50 |
intravenous |
1gm/kg (1000mg/kg) |
|
"Experimental Chemotherapy, Volume II," Schnitzer, R.J., and F. Hawking, eds. Academic Press New York, 1964Vol. 2, Pg. 249, 1964. |
rat |
LD50 |
oral |
6gm/kg (6000mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 695, 1961. |
|