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3-(2-(Trifluoromethyl)benzyloxy)-5-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide (660868-91-7)

Identification
Name:3-(2-(Trifluoromethyl)benzyloxy)-5-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide
Synonyms:Polo-like Kinase Inhibitor III
CAS:660868-91-7
Molecular Formula: C22H18F3N3O4S
Molecular Weight: 477.46
Molecular Structure: (C22H18F3N3O4S) Polo-like Kinase Inhibitor III
Properties
Density:1.455 g/cm3
Biological Activity: Selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC 50 values are 2.2 and 9.1 nM respectively). Displays > 100-fold selectivity over ~30 other kinases tested including cdk1 and cdk2. Inhibits proliferation of most tumor cells in vitro and is selective over normal diploid fibroblasts.
Storage Temperature: 2-8°C
Safety Data
 

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