2,4(1H,3H)-Pyrimidinedione,6-(trifluoromethyl)- (672-45-7)

The IUPAC name of 6-(Trifluoromethyl)uracil is 6-(trifluoromethyl)-1H-pyrimidine-2,4-dione . With the CAS registry number 672-45-7, it is also named as 2,4(1H,3H)-Pyrimidinedione, 6-(trifluoromethyl)- ; 2,4-Pyrimidinediol, 6-(trifluoromethyl)- ; 6-(Trifluoromethyl)pyrimidine-2,4(1H,3H)-dione ; 6-(Trifluoromethyl)pyrimidine-2,4-diol ; 2,4-Dihydroxy-6-trifluoromethylpyrimidine ; 6-Trifluoromethyl-pyrimidine-2,4-diol . The product's categories are pyrimidine series, heterocyclic compounds, building blocks, heterocyclic building blocks and pyrimidines. It is used as pharmaceutical intermediate.

The 6-(Trifluoromethyl)uracil can be obtained by 2-methylsulfanyl-6-trifluoromethyl-3H-pyrimidin-4-one with 10% HCl . The reation time is 8 hours.

The 6-(Trifluoromethyl)uracil can be used to synthesize other chemicals. For example: 1. It reacts with 2-chloro-1,5-dinitro-3-trifluoromethyl-benzene to get 3-(2,4-dinitro-6-trifluoromethyl-phenyl)-6-trifluoromethyl-1H-pyrimidine-2,4-dione . 2. It reacts with N,N-dimethyl-aniline to get 2,4-dichloro-6-trifluoromethyl-pyrimidine and 4-Chloro-2-N-methylanilino-6-trifluoromethylpyrimidine . 3. It also can react with 2,4-dichloro-6-trifluoromethyl-pyrimidine to obtain 4-Chloro-2-N-methylanilino-6-trifluoromethylpyrimidine .

The other characteristics of this product can be summarized as: (1)#H bond acceptors: 4 ; (2)#H bond donors: 2 ; (3)Index of Refraction: 1.427; (4)Molar Refractivity: 29.79 cm³ ; (5)Molar Volume: 115.8 cm³ ; (6)Polarizability: 11.81×10^-24 cm³ ; (7)Surface Tension: 31.7 dyne/cm ; (8)Enthalpy of Vaporization: 66.6 kJ/mol ; (9)Vapour Pressure: 1.1E-06 mmHg at 25°C. People can use the following data to convert to the molecule structure. SMILES: FC(F)(F)C\1=C\C(=O)NC(=O)N/1; InChI: InChI=1/C5H3F3N2O2/c6-5(7,8)2-1-3(11)10-4(12)9-2/h1H,(H2,9,10,11,12).