Piperazine,1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-, hydrochloride(1:2) (67469-78-7)

Identification
Name:	Piperazine,1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-, hydrochloride(1:2)
Synonyms:	Piperazine,1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-, dihydrochloride(9CI); GBR 12909; I 893
CAS:	67469-78-7
Molecular Formula:	C28H32 F2 N2 O . 2 Cl H
Molecular Weight:	523.49
InChI:	InChI=1/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
Molecular Structure:
Properties
Solubility:	DMSO: >5 mg/mL
Appearance:	white solid
Biological Activity:	Potent, competitive inhibitor of dopamine uptake (K i = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC 50 = 48 nM). Centrally active following systemic administration.
Color:	white
Safety Data