Propanoic acid,3-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester (68181-17-9)

The 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester with the cas number 68181-17-9, is also called 1-[1-Oxo-3-(2-pyridyldithio)propoxy]pyrrolidine-2,5-dione. Its EINECS registry number is 269-034-3. This chemical is white solid and belongs to the following product categories: (1)Nitric Oxide Reagents; (2)Cross Linking Reagents. This chemical is a heterobifunctional cross-linker.

Preparation: This chemical can be prepared by the reaction of N-hydroxy-succinimide and 2-Carboxyethyl-(2-pyridyl)-disulfid. This reaction needs reagent dicyclohexylcarbodiimide and solvent tetrahydrofuran.The reaction needs at temperature of 0 ºC for 1 h, then 20 ºC for 2 h. The yield is 80%.

Uses: This chemical can react with dimethylamine, to product N,N-dimethyl-3-(pyridin-2-yldisulfanyl)-propionamide. This reaction needs reagent N,N-diisopropyl-N-ethylamine, solvent CH₂C_l2, methanol and H₂O at ambient temperature. The reaction time is 48 hours. The yield is 50%.

When you are using this chemical, please be cautious about it as the following: (1)Irritating to eyes, respiratory system and skin; (2)In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; (3)Wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: N1(C(CCC1=O)=O)OC(CCSSc1ncccc1)=O
(2)InChI: InChI=1/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2