6-Cyanonicotinic acid (70165-31-0)

The 6-Cyanonicotinic acid is an organic compound with the formula C₇H₄N₂O₂. The systematic name of this chemical is 6-cyanopyridine-3-carboxylic acid. With the CAS registry number 70165-31-0, it is also named as 3-Pyridinecarboxylic acid, 6-cyano-. The product's categories are Nitrile; Carboxylicacid. Besides, it should be stored in a cool, dry place.

Physical properties about 6-Cyanonicotinic acid are: (1)ACD/LogP: 0.16; (2)ACD/LogD (pH 5.5): -2.4; (3)ACD/LogD (pH 7.4): -2.97; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 4; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 1; (11)Polar Surface Area: 62.98 Å²; (12)Index of Refraction: 1.596; (13)Molar Refractivity: 35.39 cm³; (14)Molar Volume: 103.9 cm³; (15)Polarizability: 14.03×10^-24cm³; (16)Surface Tension: 78.2 dyne/cm; (17)Density: 1.42 g/cm³; (18)Flash Point: 193.2 °C; (19)Enthalpy of Vaporization: 68.14 kJ/mol; (20)Boiling Point: 395.9 °C at 760 mmHg; (21)Vapour Pressure: 5.59E-07 mmHg at 25°C.

Preparation: this chemical can be prepared by 1-Oxy-nicotinic acid, Hydrocyanic acid and Sodium salt. This reaction will need reagent Triethylamine, Chlorotrimethylsilane and solvent Dimethylformamide. The reaction time is 10 hours with reaction temperature of 100 - 110 °C. The yield is about 76%.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed. Besides, this chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.