Biological Activity: | Potent and selective inhibitor of noradrenalin uptake (K i values are 1.1, 129 and > 10000 nM for rat NET, SERT and DAT respectively). Displays > 1000-fold selectivity over α -adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active, clinically used antidepressant. |