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Amisulpride (71675-85-9)

Identification
Name:Amisulpride
Synonyms:4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-o-anisamide;Aminosultopride;4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxy-benzamide;Amisulprida [INN-Spanish];Benzamide, 4-amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxy-;Benzamide,4-amino-N-[(1-ethyl-2- pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2- methoxy-;4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-anisamid;4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide;Amisulpridum [INN-Latin];Solian;DAN 2163;Methyl ammonia mosapride;
CAS:71675-85-9
EINECS: 275-831-7
Molecular Formula: C17H27N3O4S
Molecular Weight: 369.48
Molecular Structure: (C17H27N3O4S) 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-o-anisamide;Aminosultopride;4-amino-N-[...
Properties
Melting Point: 124-128oC
Density:1.2 g/cm3
Refractive index:1.545
Water Solubility:Soluble to 50 mM in 1eq. HCl and to 50 mM in DMSO
Solubility:Soluble to 50 mM in 1eq. HCl and to 50 mM in DMSO
Appearance:White or almost white crystalline powder
Specification:
Off-White Solid
usageEng:Neuroleptic agent, an analogue of sulpiride. Used as an antipsychotic. Dopamine receptor antagonist
Safety Statements:22-24/25
22:Do not breathe dust
24/25:Avoid contact with skin and eyes
Biological Activity: Potent, selective dopamine D 2 and D 3 receptor antagonist. K i values are 2.8 and 3.2 nM respectively for human D 2 and D 3 and > 1000 nM for human D 1 , D 4 and D 5 receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D 2 /D 3 receptors at higher doses. Preferentially interacts with limbic D 2 -like receptors in vivo . Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.
Color: white
Usage:

Neuroleptic agent, an analogue of sulpiride. Used as an antipsychotic. Dopamine receptor antagonist

Safety Data
Hazard Symbols Xn:Harmful
 

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