Felodipine (72509-76-3)

Identification
Name:	Felodipine
Synonyms:	Hydac;Munobal;Plendil;Prevex;Splendil;dl-Felodipine;3,5-Pyridinedicarboxylicacid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester(9CI);Agon;Delmuno;Feloday;Flodil;H 154/82;
CAS:	72509-76-3
Molecular Formula:	C₁₈H₁₉Cl₂NO₄
Molecular Weight:	384.26
InChI:	InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
Molecular Structure:
Properties
Melting Point:	142-145 oC
Flash Point:	239oC
Boiling Point:	471.5oCat 760 mmHg
Density:	1.277 g/cm3
Water Solubility:	insoluble
Solubility:	insoluble
Appearance:	White or light yellow crystalline powder
Specification:	Interactions: Recent findings have suggested that felodipine in combination with grapefruit juice will make toxic effects. Oral administration of felodipine is first metabolized in the gastrointestinal tract and liver by the enzyme CYP3A4. Grapefruit juice contains bergamottin that is found to have an inhibiting effect over this enzyme, so as a result the bioavailability of the drug increases, raising the risk for abnormal side effects.
Biological Activity:	L-type Ca 2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.
Flash Point:	239oC
Storage Temperature:	Store in original container in a cool dark place.
Color:	light yellow
Usage:	A dihydropyridine calcium channel blocker
Safety Data
Hazard Symbols	Xn: Harmful

Other Product

FELODIPINE